Этабоксам

Description

Etaboxam is a fungicide of the thiazolecarboxamide group, a specialized drug against oomycetes, a group of pathogens that includes pathogens of late blight and peronospora. The mechanism of action is associated with inhibition of beta-tubulin assembly, which disrupts the mitotic division of pathogen cells. It has systemic properties, is transported along the xylem of the plant after soil application, and also moves translaminarly - through the thickness of the leaf blade.

Basic Attributes

• CAS No: 162650-77-3
• Chemical formula: C14H16N4OS2
• Chemical name: (RS)-N-(alpha-cyano-2-thienylmethyl)-4-ethyl-2-(ethylamino)-1,3-thiazol-5-carboxamide
• Molecular weight: 320.439
• Exact weight: 320.43
• EU number: 605-299-7
• DSSTox ID: DTXSID2057994
• HS code: 29349990
• PSA specification: 134
• XLogP3: 2.69

Physico-chemical characteristics

• Density: 1.323±0.06 g/cm3 (predicted value)
• Melting point: 185-187 °C, solvents for recrystallization - ethanol, toluene
• Refractive index: 1.643

Mechanism of action and activity

Etaboxam inhibits the assembly of beta-tubulin into microtubules necessary for the mitotic division of oomycete fungal cells, which blocks germination, mycelial growth and sporulation of the pathogen. In laboratory tests, it showed inhibitory activity against isolates of the potato and tomato late blight pathogen Phytophthora infestans at minimum inhibitory concentrations from 0.1 to 0.5 mg/l, as well as against isolates of Phytophthora capsici at concentrations from 1.0 to 5.0 mg/l. The drug inhibits the penetration of the pathogen through the surface of the plant and specifically inhibits the growth of mycelium and sporulation of Phytophthora infestans, while it relatively weakly suppresses the germination of zoospores and cysts of the pathogen.

Scope of application

Systemic fungicide with preventive, curative, systemic and residual action to protect potatoes, tomatoes, grapes and other susceptible crops from oomycete pathogens - late blight and peronospora. It is introduced into the soil and transported along the xylem to the above-ground parts of the plant, and is additionally distributed throughout the leaf thickness due to translaminar movement.

Safety Information

• Precautions: P273, P391, P501
• Hazard Statement: H400 - Very toxic to aquatic life

GHS classification: signal word “Warning”, H400 confirmed 100% of notifications, data aggregated for 89 companies from 1 notification to the ECHA C&L register.

Storage and transportation conditions

Store in original sealed containers in a cool, dry place, away from food and feed. Very toxic to aquatic organisms (H400) - when working, do not allow the working solution and rinsing water to enter water bodies, observe buffer zones when processing fields near water bodies (P273, P391), dispose of residues in accordance with established standards (P501).