Малолактомицин А

Description

Malolactomycin A is a natural 40-membered polyol macrolide, an antibiotic from the culture fluid of streptomycetes. The structure of malolactomycins A and B has been established as new for the group of macrolide antibiotics: the molecules contain a hemiacetal fragment, a malonic acid ester residue and a dimethylguanidine group. Malolactomycins A and B are positional isomers at the position of the malonate residue and are converted into each other by transesterification. Compounds of this series exhibit antifungal effects. The formula C63H111N3O20 and molecular weight match the PubChem entry (CID 6917053).

Basic Attributes

• CAS No: 135667-47-9
• Chemical Formula: C63H111N3O20
• Molecular weight: 1230.56000
• Exact weight: 1229.77609294
• PSA Specifications: 398.54000
• XLogP3: 3.60230

Physico-chemical properties according to the card

• Density: 1.27 g/cm³
• Boiling point: 1245 °C at 760 mm Hg. Art.
• Flash point: 706.8 °C
• Refractive index: 1.562
• Steam pressure: 0 mmHg Art. at 25 °C

Structural feature: malonate isomerism

The malonic acid residue in the molecule can be located at different hydroxyl groups of the ring. Forms differing in the position of this residue are designated malolactomycins A and B; they are interconverted by transesterification. This property is taken into account when isolating, purifying and storing the drug: a shift in equilibrium changes the ratio of isomers in the sample.

Area of ​​use

• reference sample for studying macrolide antibiotics of streptomycetes
• studies of antifungal activity of natural compounds
• work on the chemistry of polyol macrolides, including the study of transesterification of the malonate residue

Storage and handling

Hazard classification, H and P phrases and transport codes are not included in the card. Store in an airtight container at a low temperature, away from light and moisture. Wear gloves and safety glasses and remove the sample without dust.