Пелирин

Description

Pelirine is a monoterpene indole alkaloid isolated from the roots of Rauvolfia perakensis, a plant of the Apocynaceae family. The structure was established as 10-methoxyepiaffinine: the conclusion was made by comparing spectral data with 11-methoxyepiaffinine synthesized from gardnerine and confirmed by X-ray diffraction analysis. The second name of the substance in the catalogs is 10-methoxyepiaffinine.

Basic Attributes

• CAS No.: 30435-26-8
• Chemical formula: C21H26N2O3
• Molecular weight: 354.44274
• Density: 1.240 ± 0.06 g/cm³ (predicted value)
• Melting point: 130–131 °C (crystallization from aqueous methanol)

Origin and class

The genus Rauvolfia has about sixty species and is distributed in America, Africa, Asia and Oceania. Plants of the genus are a source of monoterpene indole alkaloids; This group also includes reserpine, ajmaline, and rayubazine. Pelyrine belongs to the affinine-epiaffinine type, methoxylated at position 10 of the indole core.

Scope of application

Analytical standard for chromatographic profiling of rauwolfia alkaloids: confirmation of the authenticity of raw materials, assessment of the ratio of alkaloids in extracts, metrology of HPLC and LC-MS methods. Reference substance in works on the chemistry and biosynthesis of indole alkaloids of Apocynaceae. Available in milligram and ten milligram portions for laboratory use.

Storage and handling

Indole alkaloids are sensitive to light, oxygen and elevated temperature, so the substance is stored in a closed dark glass container in the refrigerator, and solutions are prepared immediately before analysis. Work with gloves and safety glasses, take the attachments under a hood. Suppliers do not provide a complete GHS card for the substance, so it should be handled as a potentially toxic alkaloid.