Казинол У

Description

Kazinol U is a prenylated flavan isolated from Broussonetia kazinoki (paper mulberry, mulberry family). Structure according to the card: 4-[(2R)-3,4-dihydro-7-hydroxy-2H-1-benzopyran-2-yl]-3-(3-methyl-2-buten-1-yl)-1,2-benzenediol. The molecule combines a chroman core with a hydroxyl at position 7, a catechol fragment and a prenyl (isopentenyl) substituent.

Basic Attributes

• CAS No: 1238116-48-7
• Chemical formula: C20H22O4
• Molecular Weight: 326.38628
• Exact weight: 326.151794
• Catalog section: flavonoids

Physico-chemical characteristics

• PSA: 69.92
• XLogP3: 4.57
• Density: 1.243 ± 0.06 g/cm³ (predicted)
• Boiling point: 538.8 ± 50.0 °C (predicted)
• Flash point: 279.7 ± 30.1 °C
• Refractive index: 1.631

Biological activity

• suppression of melanogenesis in mouse and human melanoma cells: decrease in the level of tyrosinase and related proteins (TRP) against the background of activation of AMP-dependent protein kinase and phosphorylation of MAPK (Lim et al., British Journal of Pharmacology, 2019)
• AMPK activation via LKB1 kinase
• cytoprotective effect: protection of β-cells from apoptosis caused by the cytokines interleukin-1β and interferon-γ, with suppression of NF-κB activity

Scope of application

• reagent in skin pigmentation research and development of depigmenting compounds
• tool for working on the LKB1–AMPK and NF-κB signaling pathways
• subject of research on pancreatic β-cell protection
• reference standard for the analysis of prenylated flavans of Broussonetia

Product form

Dispensed in small portions, typical purity - no less than 95% by HPLC; in reagent catalogs it is found under the code SML3616.

Storage and handling

The catechol fragment is oxidized in air, especially in a humid and alkaline environment. Keep the container closed, in a dry and dark place at a low temperature; Prepare solutions in DMSO immediately before the experiment. The product is intended for laboratory research.