Специфиозид

Description

Specioside is an iridoid glycoside, an ester of catalpol with (E)-p-coumaric acid at position 6; hence the second name 6-O-(E)-p-coumaroylcatalpol. First isolated from Catalpa speciosa (family Bignoniaceae), also found in Catalpa bignonioides and Stereospermum suaveolens. The commercial form is a substance of analytical purity isolated from plant raw materials, the consumer is a laboratory, not production.

Identification

• CAS No.: 72514-90-0
• Chemical formula: C24H28O12
• English name: Specioside
• Synonyms: 6-O-(E)-p-coumaroylcatalpol, (−)-specificoside
• Class: iridoids, iridoid glycosides

Basic Attributes

• Molecular Weight: 508.47192
• Exact weight: 508.47
• PSA Specifications: 188
• XLogP3: −0.9

What do these numbers mean for work?

Negative XLogP3 at PSA 188 - the molecule is hydrophilic. Working solutions are prepared in water, methanol, aqueous ethanol or DMSO; The substance does not exist in non-polar solvents. Extraction from raw materials is carried out using water-alcohol mixtures, and purification is carried out by reverse phase chromatography.

Scope of application

• analytical standard for the quantitative determination of iridoids in Catalpa, Stereospermum and other bignonium raw materials using HPLC-UV and HPLC-MS methods
• marker of authenticity of plant materials and extracts
• object of pharmacological screening: the compound is described to increase the resistance of Caenorhabditis elegans to oxidative stress caused by juglone and to heat stress - in a dose-dependent manner, with an increase in life expectancy
• starting compound for the preparation of catalpol derivatives

Storage and handling

Keep in a tightly closed container, in the dark, protect from moisture. The ester bond with coumaric acid and the glycosidic bond are destroyed by heating and in an acidic or alkaline environment, so solutions are prepared before use and are not stored for future use.