Кудраксантон D

Description

Cudraxanthone D is a natural xanthone, a secondary metabolite of the plant Cudrania tricuspidata (Cudrania tricuspidata, mulberry family). Xanthones are a class of oxygenated heterocyclic polyphenols based on a dibenzo-γ-pyrone core, widely represented in the genera Cudrania, Garcinia and related taxa.

Basic Attributes

• CAS No: 96552-41-9
• Chemical formula: C24H26O6
• Molecular weight: 410.45964
• Exact weight: 410.172943
• Specifications PSA: 100.13000
• XLogP3: 5.34

Physico-chemical characteristics

• Density: 1.3±0.1 g/cm3
• Boiling point: 620.1±55.0 °C at 760 mm Hg. Art.
• Flash point: 212.6±25.0 °C
• Refractive index: 1.614

Origin and class of compound

Isolated from the root of Cudrania tricuspidata, a plant traditionally used in oriental medicine; extracts of these raw materials have been studied, in particular, for inhibitory activity against liver and serum xanthine oxidase, which is associated with a decrease in uric acid levels. Cudraxanthone D belongs to prenylated xanthones, a structural subclass characteristic of the genus Cudrania, where isoprenoid side chains are attached to the xanthon core, increasing the lipophilicity of the molecule (XLogP3 5.34) compared to non-prenylated xanthones.

Scope of application

Reference compound for phytochemical analysis and standardization of Cudrania tricuspidata raw materials, an object of pharmacological research in the framework of the study of biologically active xanthones of this plant, including in the context of the hypouricemic activity of kudrania root extracts and the search for xanthine oxidase inhibitors.

Related xanthones of the genus Cudrania

The root of Cudrania tricuspidata contains a whole series of structurally related prenylated xanthones - in addition to kudraxanthone D, cudraxanthones of other letter designations and related prenylflavonoids have been described. This diversity of prenylated polyphenols is typical of the genus Cudrania and is considered a source of compounds for the search for inhibitors of xanthine oxidase and other enzymes involved in purine metabolism.

Structural features of the xanthone core

The dibenzo-γ-pyrone skeleton of xanthones provides the molecule with a flat aromatic structure with several possible hydroxylation and prenylation positions, which determines a wide range of biological activities of this class of natural compounds - from antioxidant to antitumor, depending on the nature and position of the substituents.

Storage and handling

Store in an airtight container in a cool, dry place, protected from light - the polyphenolic structure of the xanthone core is sensitive to oxidation upon prolonged contact with air. Work - with standard personal protective equipment for plant polyphenolic standards and biologically active substances of unknown acute toxicity profile.