Ханцинон С

Description

Hancinone C belongs to neolignans—dimeric phenylpropanoids in which the bond between monomers is not formed according to the β,β'-type of classical lignans. The molecule is constructed as a cyclohexadienone core with an allylic group, two methoxy groups and a substituent bearing a 3,4,5-trimethoxyphenyl moiety. The compound is described among the neolignans of the aerial parts of peppers of the genus Piper (Piper wallichii). Substances in this series have been shown to inhibit platelet aggregation caused by platelet activating factor (PAF), as well as antioxidant and anti-inflammatory activity.

Basic Attributes

• CAS No: 111843-10-8
• Chemical formula: C23H28O6
• Molecular weight: 400.471
• Accurate weight: 400.189
• PSA specifications: 63.2
• XLogP3: 4

Character of the molecule

An XLogP3 value of 4 indicates pronounced lipophilicity: the substance is better soluble in organic solvents than in water; working solutions are usually prepared in DMSO or alcohols. The polar surface 63.2 corresponds to six oxygen atoms in the methoxy and carbonyl groups.

Scope of application

• standard for phytochemical analysis of Piper extracts and monitoring of neolignan content
• studies of antiplatelet action in relation to PAF-induced platelet aggregation
• screening for antioxidant and anti-inflammatory activity of neolignans
• work on establishing the structure and synthesis of compounds of the chancinone series

Safety Information

GHS classification, hazard statements, labels, transport codes and LD50 data for CAS 111843-10-8 are not included in the original card and are not indicated here. The operating procedure is standard for natural reagents: fume hood for hanging, gloves, safety glasses.

Storage

Keep in a tightly closed container, in a dry place without direct light. Prepare solutions in organic solvents immediately before use.