Магнолианин

Description

Magnolianin is a trilignan, that is, a compound assembled from three lignan fragments with a 1,4-benzodioxane ring in the structure. Isolated from the bark of Magnolia obovata. Molecular weight over 800 with the formula C54H50O8 is one of the largest molecules among natural lignans of this series.

Basic Attributes

• CAS No: 147663-91-0
• Gross formula: C54H50O8
• Molecular weight: 827.0
• Exact weight: 826.35056855
• Density: 1.188 ± 0.06 g/cm³ (calculated value)
• Boiling point: 850.5 ± 65.0 °C (calculated value)

Density and boiling point are given by calculation - in the original card they are marked as predicted.

Biological activity

Magnolianine is a potent 5-lipoxygenase inhibitor. In experiments on the cytosol of guinea pig polymorphonuclear leukocytes, the substance suppressed the formation of 5-HETE with an IC50 of 0.45 μM. 5-lipoxygenase is a key enzyme in the biosynthesis of leukotrienes, therefore the compound is classified as an anti-inflammatory agent of the lipoxygenase pathway. Antimicrobial activity has also been described.

Scope of application

• reference standard for phytochemical analysis of Magnolia obovata bark
• tool in studies of the lipoxygenase pathway of arachidonic acid metabolism
• Comparator compound for screening 5-lipoxygenase inhibitors
• work on the anti-inflammatory and antimicrobial properties of magnolia lignans

Storage and handling

Store in a tightly closed dark glass container, in a cool, dry place, out of direct light. Phenolic groups are oxidized by atmospheric oxygen, so opened packaging is not stored for a long time. When working, use gloves and safety glasses.