Тевклатриол

Description

Teuclatriol (teuclatriol) is a natural sesquiterpene alcohol of the guianan series. The systematic name reflects the structure: (1S, 3aR, 4R, 7S, 8R, 8aR)-decahydro-1,4-dimethyl-7-(1-methylethyl)-1,4,8-azulenetriol, that is, a saturated azulene (hydrazulene) framework with three hydroxyl groups. Isolated from the herb Teucrium leucocladum, as well as from the Iranian sage species Salvia mirzayanii.

Biological activity

The substance was obtained from the Salvia mirzayanii extract by fractionation guided by biological activity: selection was based on its antiproliferative effect on human lymphocytes. An immunoinhibitory and anti-inflammatory effect has been described; the mechanism is associated with suppression of activation of the transcription factor NF-kappaB, followed by a decrease in the production of proinflammatory cytokines and other mediators.

Basic Attributes

• CAS No: 152110-17-3
• Chemical formula: C15H28O3
• Molecular weight: 256.38102
• Exact weight: 256.204
• PSA specifications: 60.7
• XLogP3: 1.8
• Compound class: guayan sesquiterpene, azulene triterpene alcohol

Physico-chemical characteristics

• Density: 1.075 plus or minus 0.06 g/cm3 (predicted)
• Boiling point: 382.1 plus or minus 37.0 °C (predicted)

Scope of application

• reagent for immunological and anti-inflammatory studies, including the NF-kappaB signaling pathway
• analytical standard for phytochemical analysis of Teucrium and Salvia raw materials
• model compound in works on the chemistry and synthesis of sesquiterpenes

Safety Information

Laboratory reagent. Wear gloves and safety glasses, take the sample in a fume hood, and avoid inhaling dust.

Storage conditions

The container is tightly closed, stored away from light and moisture, separately from food products. Remains should be transferred to a licensed operator.