Ацетат Пикразина В

Description

Picrazine B acetate is an acetyl derivative of the quassinoid picrazine B. Quassinoids are highly oxidized triterpenoid degroments known as the bitter principles of plants in the family Simaroubaceae. The parent picrazine B is isolated from the bark of Picrasma quassioides (Japanese quassia); it is also listed in the literature as nigakylactone I and simalicalactone B. Acetylation of the hydroxyl group increases lipophilicity and facilitates chromatographic work with the compound.

Basic Attributes

• CAS No.: 30315-04-9
• Chemical Formula: C23H30O7
• Molecular weight: 418.5 g/mol
• Exact weight: 418.199158
• NSC Number: 626672
• PSA Specifications: 95.97000
• XLogP3: 2.01

Physico-chemical characteristics

• Density: 1.3 ± 0.1 g/cm³
• Boiling point: 582.8 ± 50.0 °C at 760 mm Hg. Art.
• Flash point: 252.1 ± 30.2 °C
• Refractive index: 1.543

Origin and activity of parent compound

Picrasins A–G were isolated from Japanese quassium Picrasma quassioides as bitter principles (simarubodids). Picrasin B is also found in Soulamea pacheri and Quassia africana. It has been described to have antimalarial activity and use in traditional African medicines; Antifeedant and insecticidal effects against cabbage moths were noted. Alkaline hydrolysis converts picrazine B to neoquassin.

Scope of application

• standard sample for phytochemical analysis of Picrasma quassioides raw materials
• reference compound in quassinoid chemistry studies
• material for work on the dependence of activity on structure in the series of bitter principles Simaroubaceae

Storage and handling

Non-volatile solid. The container is tightly closed, the room is dry and cool, exclude light. The acetate group hydrolyzes in an alkaline environment, so contact with alkalis and moisture is avoided. Wear gloves and avoid dust.